22nd Annual Green Chemistry & Engineering Conference | June 18-20, 2018 | Portland, Oregon

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Advancing Sustainable Solutions by Design

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Greener Approaches to Therapeutic Synthetic Polypeptides– Oral
Tuesday PM

Symposium Organizer: Kristi Budzinski (Genentech); ACS GCI Pharmaceutical Roundtable

Biologics are a widely diverse group of therapeutic compounds including peptides, antibodies, non-antibody proteins, and vaccines and are a growing sector of the pharmaceutical market.  Typically manufactured by living cells, biologics generate less chemical waste than small molecule pharmaceuticals but consume large quantities of water and energy and significant volumes of single-use plastics and filters. Several initial environmental analyses have been performed for biologics production and underscore the need for incorporating sustainability into the development process. As a half-day symposium, this session aims to highlight currents efforts in biologics process research and development and manufacturing to incorporate green chemistry and engineering principles. Specifically it will highlight innovative engineering processes and technologies that can reduce energy and water usage and waste generation and tools for measuring environmental impacts along the production chain.  Next generation therapeutics such as antibody drug conjugates (ADCs), therapeutic polypeptides, antisense oligonucleotides (ASOs), bispecific antibodies and related compounds are changing the landscape of bioprocessing and small molecule development. This session will explore how green chemistry and engineering practices can contribute to the sustainable design of bioprocess methods for next generation therapeutics.

Driving Waste Toward Zero: The Importance of Superior Process Design- Oral
Tuesday PM

Symposium Organizer: David Leahy (Bristol-Myers Squibb); ACS GCI Pharmaceutical Roundtable

Session Chair: JJ (Jingiun) Yin (Merck)

While efficient, concise and convergent synthetic routes to complex molecules are essential for their sustainable production; of equal importance is the efficiency of individual processes that comprises each step along the synthetic route.   Thus excellent process design enables sustainable chemical synthesis on industrial scale.  This session will explore how improved synthetic methodologies, catalysis, solvent selection, recycling, and minimization of unit operations play a vital role in process chemistry allowing waste generation to drive towards zero.

New Sustainable Synthetic Strategies Through Photoredox Catalysis- Oral
Wednesday AM

Symposium Organizer: David Leahy (Bristol-Myers Squibb); ACS GCI Pharmaceutical Roundtable

Session Chair: Neil Strotman (Bristol-Myers Squibb)

Visible light photoredox catalysis represents a new and exciting mode of catalytic activation of organic molecules, and has recently spurred intense interest across the organic chemistry community.  Photoredox catalysis has enabled the design of powerful new transformations through single-electron transfer (SET) pathways, using safe, bench stable catalysts.  This session will explore the design, and development of new photoredox transformations and their application to green and sustainable chemical synthesis.

Green Chemistry & Medicinal Chemistry are Miscible! -Oral
Wednesday PM

Symposium Organizer: Stefan Koenig (Genentech); ACS GCI Pharmaceutical Roundtable

Session Chair: Dan Richter (Pfizer)

Medicinal chemists are charged with the rapid synthesis of a large group of chemical structures to find hits for their biological target of interest and then optimize these hits these into lead candidates.  As a result of reliance on tried and true synthetic methods, non-green chemicals, solvents, and conditions are often part of the initial chemical synthesis of any given investigative compound.  These non-green synthetic procedures are then often adapted by process chemists to make large-scale deliveries in order to meet tight timelines.  However, through recent progress in developing greener methods to many common transformations, the process of drug discovery has become more sustainable and these initiatives can accelerate the pace of molecules in the pharma pipeline by facilitating more ready adaptation by process chemists.  By leveraging modern synthetic methods (C-H activation, aqueous chemistry, biocatalysis, etc.) and more practical considerations (electronic notebooks, smarter solvent choices, and chromatography minimization), speed to clinic can be enhanced because more sustainable chemistry is practiced.  Broadening the application of Green Chemistry into Medicinal Chemistry is at the leading edge of the ACS Green Chemistry Institute Pharmaceutical Roundtable’s mission and several breakthroughs will be featured in this symposium.

How to get there from Here: Sustainably- Oral
Wednesday AM

Symposium Organizer: Stefan Koenig (Genentech); ACS GCI Pharmaceutical Roundtable

Session Chair: Chris Beaudry (Oregon State University)

The efficient synthesis of complex pharmaceuticals and natural products is a longstanding problem facing the chemistry community.  As the industry gravitates towards more complex molecules in order to access new targets and therapies, it is vitally important that synthetic strategy keeps pace so that these new drugs are made available to patients.  This session will explore the importance of synthetic route design, not only to manufacture biologically active molecules in a sustainable fashion, but also to expand the scope of what chemical synthesis can offer on a commercial scale.

Advances in Continuous Chemistry: Back to the Future- Oral
Tuesday AM

Symposium Organizer: Michael Kopach (Eli Lilly); ACS GCI Pharmaceutical Roundtable

For many decades flow chemistry has been used extensively in the petrochemical industry for its increased safety, efficiency and product quality. Many of these benefits are also directly applicable to orthogonal industries. For these reasons continuous chemistry has recently been gaining interest in academia and the pharmaceutical industry. This session will focus on development of novel continuous chemistry designed to improve safety, quality and efficiency. Papers for this session should address:

New chemistries which are operated optimally in continuous flow mode.

Gas phase reactions in explosive regimes

Highly exothermic, high temperature or cryogenic processes

Integrated synthesis, work-up and analysis

Case studies with a focus on process safety and material efficiency.

Comparative analyses using metrics which measure sustainability. These include Process Mass Intensity (PMI) and Global Warming Potential (kg / CO2 eq.)

New Directions in Green Synthetic Design- Oral
Thursday PM


Bridging Green Solvent Design, Impacts, and Application- Oral
Wednesday PM

Symposium Organizer: Lindsey Soh (Lafayette College); Aaron Scurto (University of Kansas)

There is a need to find and implement green solvent alternatives especially with regards to overwhelming percentage of the solvent use that is wasted during manufacturing.  This session will provide an opportunity to discuss the need for addressing the criteria requisite to find truly sustainable alternatives.  Specific topics that will be covered are Solvent design and application, Solvent testing, and Use in commercial applicants.

Design Strategies to Maximize the Net Environmental and Human Health Benefit of Emerging Approaches to Environmental Challenges- Oral
Thursday AM & PM

Symposium Organizer: Leanne Gilbertson (University of Pittsburgh)

From agriculture to electronics, the utilization of novel chemicals and materials to achieve enhanced functionality and environmental benefit in next generation products and processes is pervasive. The green chemistry and engineering community is well aware that these technological advancements often come at a cost. In the current global climate (i.e., strains on sources and production of sufficient energy, water, and food to meet demand), ‘costs’ are not solely economic in nature, but also include environmental and human health costs. Thus, there is an opportunity to take lessons learned from modern technologies to inform the design of emerging technologies in a way that ensures a net environmental and/or human health benefit. This session aims to focus discussion on the meaning of the proposed impact-benefit tradeoff approach, methods to quantify these tradeoffs across the life cycle, how the results from that analysis can be used to inform design of next generation technologies, and provide a survey of inspirational examples across sectors. As such, the session is seeking contributions that focus on the design of chemicals, materials, technologies and processes that offer a clear potential for realization of net environmental or human health benefit.

Designing Precursors for Functional Materials Through Sustainable Chemistry- Oral
Thursday AM

Symposium Organizer: Cory Perkins (Oregon State University); Bettye Maddux ( NSF Center for Sustainable Materials Chemistry)

Toward sustainable materials chemistry:  Solution-based, additive approaches to inorganic thin films.  This session will highlight research and innovation on inorganic complexes, clusters and nanoparticles and the chemistry that makes them useful as solution-based precursors for thin film formation.

Inorganic Thin-Films: From Sustainable Design to Advanced Functionalities- Oral
Thursday PM

Symposium Organizer: Cory Perkins (Oregon State University); Bettye Maddux ( NSF Center for Sustainable Materials Chemistry)

Toward sustainable materials chemistry:  Solution-based, additive approaches to inorganic thin films. This session will highlight current research, designs, and innovations for functional thin films produced from sustainable precursor materials.


General Advances in Green Chemistry- Oral
Tuesday AM

Symposium Organizers:  Jim Hutchison (University of Oregon), Adelina Voutchkova (George Washington University)

2016 Presidential Green Chemistry Challenge Award Winners– Oral
Tuesday AM


Design of New Strategies for the Conversion of Carbohydrates- Oral
Wednesday PM

Symposium Organizer: Katalin Barta (University of Groningen, The Netherlands); Pieter Bruijnincx (Utrecht University)

The design of catalysts will have to accommodate the increased level of functionality present in the renewable biopolymers. Compared to petroleum where the goal was the selective addition of functionality, here new creative solutions are needed for depolymerization, (partial) defunctionalization and bond cleavage reactions. Especially the non-­edible fraction of renewables, lignocellulose (as well as triglycerides and other plant components) that can be part of agricultural and forestry waste materials harbors much potential as feedstock for the future, sustainable chemical enterprise. This session is comprised of presentations about the direct conversion of cellulose and the chemical conversion of the most important chemicals.

Conversion of Renewables: Catalysis, Methods and Technologies- Oral
Tuesday PM

Symposium Organizer: Katalin Barta (University of Groningen, The Netherlands); Pieter Bruijnincx (Utrecht University)

The design of catalysts will have to accommodate the increased level of functionality present in the renewable biopolymers. Compared to petroleum where the goal was the selective addition of functionality, here new creative solutions are needed for depolymerization, (partial) defunctionalization and bond cleavage reactions. Especially the non-­edible fraction of renewables, lignocellulose (as well as triglycerides and other plant components) that can be part of agricultural and forestry waste materials harbors much potential as feedstock for the future, sustainable chemical enterprise. The session will discuss polymer building blocks from fatty acids, platform chemicals and glycerol.

Design of New Strategies for the Conversion of Lignin- Oral
Wednesday AM

Symposium Organizer: Katalin Barta (University of Groningen, The Netherlands); Pieter Bruijnincx (Utrecht University)

There is urgent need to identify central platform chemicals not only for the sugar fraction, but also for lignin that is the largest renewable source of aromatics on the planet. Over the past decade, tremendous advances have been achieved in multiple related areas, but more progress is needed towards the economically viable and fully sustainable implementation of new chemical routes starting from specific classes of renewable starting materials. It is imperative that the new catalysts designed for these purposes are based on earth-­abundant materials, are atom economic and energy efficient, and contribute to the reduction of waste by better design. This session is comprised of oral pretensions regarding selective bond cleavage and homogeneous catalysis, heterogeneous catalysis, lignin to BTX, lignin to functionalized aromatics, thermal approaches

CO2 Utilization by Design: From Molecular Catalysts to Surface Chemistry- Oral
Tuesday AM & PM

Symposium Organizers: Gonghu Li (University of New Hampshire), Jonas Baltrusaitis (Lehigh University)

Carbon dioxide (CO2) is a renewable C1 feedstock for the production of chemicals, materials and fuels.  Chemical reduction of CO2 has attracted extensive research interests from scientists and engineers from all over the world.  This session will feature talks by researchers working in the field of photocatalytic and electrocatalytic CO2 reduction using molecular, heterogeneous, and hybrid systems.  This session will also serve as an educational platform to broadly disseminate knowledge and concepts of sustainability and green chemistry/engineering.


Design of Processes for Cleaner Water- Oral
Thursday AM

Symposium Organizer: Shyam Shukla (Lamar University)

Access to reliable and clean drinking water is quickly becoming a social, environmental and security concern on a global scale. The 2015 World Economic Forum reported the lack of sustainable water sources is among the top environmental risks to global security. These problems stem from a shortage of fresh water sources coupled with persistent organic pollutants (POPs) and heavy metals that are released from anthropogenic sources. The effects on aquatic ecosystems, and human life are already starting to be seen. This session is dedicated to processes that help prevent the accumulation of POPs and heavy metals from the water supply. Such processes can take the form of water treatment strategies, design of biodegradable chemicals that lack persistence and even re-design of technologies that currently contribute to the pollution of our water supply.

Green Chemistry In Consumer Products: From Demand To Supply- Oral
Tuesday AM

Symposium Organizer: Lauren Heine (Northwest Green Chemistry); Anthony Noce (Haley & Aldrich)

This proposed session examines drivers resulting from government policy, retail policy, sectoral supply chain initiatives, and NGO movements that promote the development and adoption of green chemistry and engineering in consumer products. Government policy is intended to set the framework for the management and use of chemicals in commerce.  While US federal reform remains unresolved, the trend in Europe, Asia, and individual US states is toward greater disclosure of chemical identities, assessment of hazard, and restrictions on the use of high hazard chemicals, with some explicit encouragement for the adoption of safer chemicals.

Beyond government policy, consumers are increasingly creating demand for products that are perceived to be safer.  In recent years, non-government organizations have also brought considerable pressure on retailers, manufacturers, and brands, publicly drawing attention to high hazard chemicals in products and demanding alternatives that are designed to be less hazardous.

This increasing demand for products that are not only greener, but that also are cost-competitive and perform as well or better than their existing counterparts has begun to infiltrate the product development and commercialization system, from discovery through supply chains, taking into account consumer preference and end-of-life considerations.  This has awakened chemical manufacturers and entrepreneurs to begin developing alternative chemicals and materials for common formulation ingredients such as solvents, surfactants, chelating agents, boron alternatives, uv agents, fragrances, and more.  This session will seek presentations from chemists, formulators, chemical manufacturers, consortia, and others to share case studies and success stories of how the implementation of different kinds of policy has promoted the design of greener and more sustainable consumer products.

Exploring Opportunities for Green Chemistry Educators and Researchers as Change Agents Addressing the Social and Environmental (In) Justices of Chemical Exposure- Oral
Wednesday PM

Symposium Organizer:  Edward Brush (Bridgewater State University)

Green Chemistry is the science of making smart choices in how we design, make, use and dispose of chemicals and chemical products.  Chemicals provide the function consumers demand in everyday products.  However, chemists also need to be aware of the potential unintended consequences of hazardous chemicals that are disproportionally impacting children and adults in low income, minority neighborhoods.  This violates our definition of social and environmental justice where all people, regardless of race or economic status, have the right to live, work, play and learn in healthy, safe environments.

The goal for this session is to start conversations about: the steps that chemists can take to better understand disparities in how hazardous chemicals impact society, and the need for transdisciplinary collaboration between the social sciences and green chemistry practitioners as change agents addressing the social and environmental (in) justices of chemical exposure.  Abstracts from a variety of disciplines are encouraged, especially those focusing on: (1) The current issues of social disparities related to exposure to hazardous chemicals; (2) The type of change(s) needed in chemistry education; (3) How chemistry outreach education may better inform the public on the role of chemicals in their daily lives; and (4) How the field of green chemistry might offer solutions to achieve social and environmental justice.

Education & Curriculum

Education Resources Designed to Share Sustainable Solutions to Plastics and Materials- Oral
Wednesday AM

Symposium Organizer: Jane Wissinger (University of Minnesota)

The prevalence and importance of plastics/polymers in our society and their effect on human health and the environment make this topic compelling for the classroom, laboratory, and outreach activities.  Presenters are encourage to submit their experiments and course materials illustrating how modern green technologies using renewable materials, biomaterials, safer syntheses, recycling, and design for degradation have been developed to seek solutions to current unsustainable practices.  These topics can extend to nanomaterials and biological macromolecules.  This session is open to K-12, undergraduate, and graduate levels of instruction as well as outreach audiences.

Design of Curricular Materials: Rapid fire session- Oral
Thursday PM

Symposium Organizer: Jane Wissinger (University of Minnesota)

This animated symposium will provide educators the opportunity to share how they are designing new and engaging laboratory experiments and lecture content which model innovations in green chemistry and green engineering.  The rapid-fire session format will allow presenters up to seven minutes to present the highlights of their design with three minutes for questions.  Speakers must be willing to participate in a panel discussion and are encouraged to share electronic materials with interested attendees.   More than one submission will be allowed, time permitting, to offer a breadth of topics.

Design of State of the Art Green Chemistry Curricula- Oral
Thursday AM

Symposium Organizer: Jim Hutchison (University of Oregon)

Last year’s session explored the future of green chemistry and engineering education and introduced the idea of developing a roadmap for education by exploring the evolving needs of a variety of stakeholders. As the roadmap evolves, green chemistry educators will need to integrate new topics into the curriculum.  This session will showcase efforts to integrate topics like life cycle thinking, appropriate use of high-throughput assays and informatics, evaluation of metrics for continuous improvement and economic success, toxicology, structural indicators of environmental and health impacts, knowledge of the innovation process, design thinking etc., into the modern chemistry and engineering curriculum.


Alternatives Assessment & De Novo Design- Oral
Wednesday AM

Symposium Organizer: Hans Plugge (3E Company, A Verisk Analytics Company); Longzhu Shen (Yale University)

There are two crucial elements in approaching the goal of sustainability in chemical products and processes:  alternatives assessment and de novo molecular design. To date the focus of both areas has been hazard reduction i.e. minimizing biological consequences. In order to design chemical products with superior functionality and efficacy while minimizing their toxicity or to derive a proper alternatives assessment as per NAS 2014, it is necessary to incorporate factors like exposure, functionality and life cycle assessment into the overall design and assessment scheme.  When considering functionality, alternatives assessments approach it posteriorly, whereas de novo design formulates it as a prior optimization problem. Presentations at the symposium should focus on integration of elements of molecular toxicology, computational chemistry, data science and exposure assessment aimed at ushering in a new era of holistic sustainability modeling for green chemical design and assessment.

Workshop on Data Uncertainty in Predictive Toxicology & Alternative Assessments- Oral
Wednesday PM

Symposium Organizer: Jakub Kostal (George Washington University)

Over the last two years we presented a course that outlined strategies for developing property- based design guidelines using various sources of in vitro and in vivo data; demonstrated how these models are relevant to comparative hazard assessment such as GreenScreen®; and presented future strategies for secure data-sharing to allow for design of more robust predictive models. We were encouraged by positive feedback from the past two years to use the workshop format as a way of introducing timely topics on chemical design that expand the horizons of both current and future developers and users. Thus, in addition to expanding upon computational approaches used in safer chemical design and predictive modeling, this year’s workshop will focus on the concept of data uncertainty and its importance in decision-making strategies and development of predictive tools. The synthesis of overlapping data sources with varying uncertainty and reliability is critical in developing robust predictive methods, yet it is one of the aspects of model development that is often undervalued or completely disregarded. We will discuss this issue from the point of view of experimentalists, modelers and practitioners involved in safer chemical design.

Workshop Synopsis


Green Chemistry Design foraA Rainbow of Colorants- Oral
Thursday PM

Symposium Organizer: Amelia Nestler (Northwest Green Chemistry); Lauren Heine (Northwest Green Chemistry); Saskia van Bergen (Washington State Department of Ecology)

Colorants represent a challenge to chemists to work on interdisciplinary teams, that include including biologists, physicists, academia, and industry to design alternative dyes and pigments that still meet the high standards of existing products while avoiding toxicity and hazardous byproducts across the life cycle. We will learn about the innovation needs by hearing about the technical challenges in maintaining dye and pigment properties while applying green chemistry and engineering principles that drive innovation.  The session will address design solutions for safer alternatives, engineering and process improvements, and innovations in pigments and design.

Green Chemistry In The Semiconductor And Electronics Supply Chain- Oral
Tuesday PM

Symposium Organizers:  Mike Kirschner (Design Chain Associates, LLC), Erin Gately (Green Electronics Council)

The electronics supply chain is one of the most complex in all of industry. Along with constant pressure for new technologies that are faster, cooler (thermally) and cheaper is the requirement to develop new chemical substances and process technologies to enable these outcomes. The development of basic – or replacement – technologies often takes five to ten years to move from concept to market. To further complicate matters the requirements for chemical and material purity, reliability and functionality exceed those of almost every other industry that produces high volume products. This session will demonstrate where and how green chemistry and engineering are making a difference across the supply chain, and what is driving the changes.

Challenges, Tools, & Innovation in the Apparel & Footwear Sector- Oral
Tuesday AM & PM

Symposium Organizer: John Frazier

The apparel and footwear industries are confronted with a number of challenges as they supply product to an expanding global population. Green chemistry and engineering innovation is increasingly seen as the way for industry to deliver high performance materials and product while simultaneously minimizing environmental impact. These sessions will highlight efforts and tools used by textile and polymer chemical suppliers, apparel manufacturers, footwear manufacturers, and brands to deliver on the demands for product performance while preserving constrained resources.


Ensuring Commercial Success in Sustainable Technology Transfer by Design- Oral
Tuesday AM

Symposium Organizer: Tom Burns  (Novozymes); Phil Sliva (Amway); ACS GCI Formulators’ Roundtable

It has been said that new product market introductions have about an 80% failure rate. While this exact number may be an urban legend, there is no question that there is a significant risk of failure for “green” product introductions, which frustrate the movement towards greater availability of more sustainable consumer products. Successful research efforts promising more-sustainable alternatives often do not translate into viable options in the marketplace, meaning sustainability opportunities are not realized, and significant investments of funding, time, and intellectual capital may never reach their full potential and expected returns. The symposium will focus on how to promote and improve the design and transfer of more sustainable technologies across the supply chain. The symposium will bring together innovators (from academia, government, small and large business) and industrial implementers to present success stories of how customer-driven product design requirements are driven back through supply chains to ensure successful commercialization.

Sustainable Chemical Separations: Accelerating Industrial Application of Less-Energy Intensive Alternatives- Oral
Wednesday AM

Symposium Organizer: Amit Sehgal (Novecare); Ettigounder Ponnusamy (MilliporeSigma); ACS GCI Chemical Manufacturers Roundtable

Separation processes central to chemicals manufacturing consume over a third of energy used in the sector. Reducing the energy required for these separations is necessary to assure the sustainability and global competitiveness of the chemical enterprise.  However, successful design and implementation of low energy intensity separations processes requires a paradigm shift.  Instead of relying on relative volatility and traditional enthalpically-driven processes such as distillation, we envision capitalizing on  exploration of the full range of intrinsic molecular properties (e.g., shape, size, dipole moment, polarizability, charge, chemical reactivity, or pairwise interactions (intra/inter-molecular and molecular-material) to drive separations. This session invites talks that focus on current and innovative strategies to explore intrinsic molecular properties that may be exploited for industrially feasible chemicals separations, identification of potential techno-economic risks, and strategies to overcome challenges.

Design of Next Generation Catalysis

Design of Homogeneous Catalysis- Oral
Thursday PM

Symposium Organizer: Adelina Voutchkova (George Washington University)

Homogeneous catalysis continues to have an integral role in the development of more sustainable chemical syntheses by pushing the envelope on development of new atom-economical alternatives to existing processes. The field is still faced with major fundamental and conceptual challenges, such as the rational design of catalysts for selective functionalization of C-H and C-C bonds, understanding the mechanisms of existing catalytic systems and the minimization of our reliance on precious metals and expensive ligands. This session will provide a forum for discussing the latest developments in experimental and theoretical catalyst design and mechanistic studies that inform the expansion of synthetic applications that meet the criteria of green chemistry. Emphasis will be placed on the use of more abundant metals in catalysis.

Design of Heterogeneous Catalysis- Oral
Thursday AM

Symposium Organizer: Adelina Voutchkova (George Washington University)

Heterogeneous catalysis plays a critical in our chemical industry. The potential for easy separation and reuse has attracted interest in developing heterogeneous catalysts for the fine chemical industry, but this fine chemical synthesis requires high selectivity. This session will focus on the development of new heterogeneous and supported catalysts that offer superior stability, selectivity and activity relative to existing systems, or facilitate a novel atom and energy-economical transformations. We shall discuss the latest developments in design and characterization of new heterogeneous catalysts, as well as insights into mechanisms and novel applications.  Special emphasis will be placed on the development of heterogeneous catalysts that offer enantioselectivity, avoid need for additives and/or solvents, as well as catalysts that can be applied for continuous flow processes. We hope this interdisciplinary session will bridge materials chemistry, synthetic chemistry and chemical engineering, as well as academia and the chemical industry.

Sustainable Strategies for Organic Synthesis Using Biocatalysis- Oral
Wednesday PM

Symposium Organizer: Animesh Goswami (Bristol-Myers Squibb); ACS GCI Pharmaceutical Roundtable

The goal of this session is to cover all aspects of sustainable strategies for organic synthesis using biocatalysis, e.g. identification of novel biocatalytic reactions, development of biocatalytic processes, industrial application of biocatalysis, and directed evolution of enzymes for extending and improving biocatalysis.

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June 18 - 20, 2018
Portland Hilton & Executive Tower
Portland, Oregon