Development of Novel Enzymes for Efficient Synthesis
Symposium Organizer: Jim Lalonde, Codexis
There has been tremendous advancement over the last 5 years in our ability to develop enzymes that can perform non-natural reactions desired by chemists and are capable of acting on non-natural substrates. These engineered enzymes can catalyze such reactions with high volumetric productivity. The progression of biocatalysis from hydrolytic enzymes for kinetic resolution, through functional group transformation enzymes, to ones capable of convergent couplings has led to increasing utility of biocatalysis in efficient synthesis. This session will focus on the latest advancements in the engineering of novel enzymes and their application to efficient synthesis of pharmaceuticals and chemicals.