Green Fluorine Chemistry: Development of Efficient Green Methods and Reagents for Fluorination
Symposium Organizer: Dr. Thomas Mathew, Research Scientist, Loker Hydrocarbon Research Institute, University of Southern California
Introduction of fluorine significantly alters the physical, chemical and biological properties of a compound. Presence of fluorine has shown profound changes in the pharmacological properties of many important therapeutic drugs. Currently, about 20-25% of the drugs in market contain fluorine. Therefore, for the synthesis of many effective compounds in the agrochemical, pharmaceutical and material science arena, development of reagents and methods for the feasible introduction of fluorine is of great significance. Synthesis of these fluorinated organics often involves the use of reagents which are corrosive and toxic (such as HF) or those having low “F” content (such as Selectfluor®, resulting in low atom economy). However, during the past two decades intense efforts in developing safer reagents and sustainable reaction protocols have been reported. In the symposium titled “Green Fluorine Chemistry: Development of Efficient Green Methods and Reagents for Fluorination”, recent studies on fluorination and fluoroalkylation with tamed fluorinating agents and reagents with greater atom economy under environmentally benign conditions will be presented.