Twenty-seventh Annual Green Chemistry & Engineering Conference

Achieving Sustainable Products Through Molecular Design with Reduced Toxicity

Session Organizers: Karolina Mellor, Yale University; Phillip Coish, Yale University

In the recent years, chemical safety related to chemical products has become a topic of concern for scientists, business leaders and public sphere. In response, there has been a significant effort to identify biological mechanisms that can lead to adverse outcomes to human and environmental health and to develop guidelines and models for chemical designers to allow them to develop products which are functional but do not pose a threat to human and environment. Advancements in the design and development of safer chemicals and products can only come through interdisciplinary effort by chemists, engineers and toxicologists. Despite ongoing efforts to cross-pollinate the these fields, significant further progress is necessary. This session aims to facilitate cross-pollination by engaging leading experts from industry, academia and government in mechanistic and predictive toxicology, as well as molecular design for safety. The experts will engage chemists and engineers at the conference by translating their contributions into tangible and practical knowledge that can be applied to designing new products and evaluating existing ones.  The session will facilitate interaction through a panel discussion, short presentations and interactive discussions of best practices in research and industry.

Green Chemistry & Engineering Poster Session

Session Organizers: Julie Haack, Assistant Department Head and Senior Instructor, University of Oregon; Richard Blackburn, Associate Professor, University of Leeds

Abstracts submitted to the poster session must meet the following criteria:
• Meets the definition of green chemistry or green engineering
• Potential impact on the field
• Development of idea
• Originality
• Conclusions supported by data

Continuous Processing – An Enabling Technology for Green Chemistry

Charles D. Papageorgiou, Associate Director, Takeda Pharmaceuticals

Continuous processing and flow chemistry are becoming increasingly common technologies used in the manufacture of active pharmaceutical ingredients. This symposium will focus on both chemistry and engineering solutions that have enabled process intensification, seamless scale-up as well as the development of environmentally friendly processes. Case studies will be presented from leading academics and industrialists highlighting the use of such technologies as well as the development of suitable manufacturing strategies.

Emerging Technologies to Enable Sustainable Organic Synthesis – Special Organic Chemistry Student Session

Session Organizer: David Leahy, Associate Director, Process Chemistry, Takeda Pharmaceuticals

The development of new synthetic methodologies and strategies has been the cornerstone upon which sustainable industrial processes are built.  The pure research advances arising from academia fuel the world’s industrial innovation, while also training the scientific leaders of tomorrow.  This special session highlights the research of graduate students and post-doctoral fellows across the broader organic chemistry community which has the potential to impact sustainable industrial chemistry. The ACS GCI Pharmaceutical Roundtable will provide 8 travel grants of up to $1000 to attend the conference and provide a 20 minute oral presentation during this session. A poster session will accommodate additional presenters. All presenters will be invited to attend the Student Conference Kick-off, and the ACS GCI 8th Annual Industrial Roundtable Poster reception during the conference.

Transforming Consumer and Industrial Products by Material and Chemical Innovations

Session Organizers: John Frazier, Senior Technical Director, Hohenstein Institute of America; Scott Echols, Scott Echols Group, LLC; Robert Buck, Technical Fellow on Sustainability, The Chemours Company

Material and chemical manufacturers are redefining what they make, how they make it and how their inputs impact the processes and footprint for creating consumer and industrial products. Greener, more sustainable materials, chemistry and engineering are widely embraced as the way to create and deliver high performance products, minimize environmental impacts and advance circular life cycles. In this session, material, chemical and process innovations transforming consumer and industrial products will be presented. Papers describing research efforts and commercial successes in products such as apparel and footwear as well as in the automotive, home furnishings, and electronics accessories sectors are requested.

Educational Initiatives in Sustainable Polymers and Materials

Session Organizers: Jane E. Wissinger, Professor, University of Minnesota; Michael T. Wentzel, Assistant Professor, Augsburg University

This symposium seeks to demonstrate how educators are engaging students in the classroom and laboratories by sharing new innovations in sustainable materials. Society’s dependence on plastics and other resilient fossil-fuel based materials, as well as their potentially negative impact on human health and the environment, is a topic that resonates with students of all levels. We are seeking abstracts which illustrate the use of green methodologies to prepare products which are: derived from renewable feedstocks; designed for degradation; reprocessed and/or recycled; or inherently safer. Of special interest are curriculum materials which meet the 2015 Committee on Professional Training Guidelines requirements to include synthetic polymers, biological macromolecules, supramolecular aggregates, meso-or nanoscale materials and simultaneously include green chemistry and engineering principles. The session is open to K-12, undergraduate, and graduate instruction as well are outreach initiatives. A goal of the symposium will be for each presenter to provide a live or videotaped demonstration of their projects to share with the audience.

Innovative Chemistry and Process Development for Sustainable Small Molecule Manufacturing (Invited Presenters Only)

Session Organizer: Kevin Maloney, Director, Process Chemistry, Merck

In the past two decades, Green Chemistry has challenged chemists to consider environmental impacts in developing synthetic methodologies and designing manufacturing processes. Despite these efforts, the pharmaceutical industry is among the largest waste producing sectors in all chemical industries, partly due to its typical requirements of multi-step synthesis and stringent regulatory quality standards. While efficient, concise, and convergent synthetic routes to complex molecules are essential for their sustainable production; of equal importance is the efficiency of individual processes that comprise each step along the synthetic route. Therefore, innovative chemistry and process development are instrumental in the design and development of green and sustainable small molecule manufacturing processes. This session will explore how innovative synthetic methodologies, prediction tools, high throughput experimentation, catalysis, solvent selection, recycling, and minimization of unit operations play a vital role in developing a green and sustainable process.

Charting the Course to Sustainable Chemistry in the Supply Chain (Invited Presenters Only)

Session Organizers: Jennifer Y. Tanir, Founder, Toward Safer LLC; M. Barclay Satterfield, Eastman Innovation Center Leader, Eastman Chemical Company

One of the barriers to the implementation of sustainable chemistry is strong integration and acceptance throughout the supply chain. Despite many individual single-product or single-company successes, or a few advances in limited sectors’ supply chains, there is still a need for widespread agreement on sustainability goals and cooperation throughout supply chains. This 1-day workshop will focus on formulated household products and attempt to distill the learnings from individual successes into a plan for widespread adoption. The workshop will build on related conversations at the 2017 GC&E Conference and a Green Chemistry article by the ACS GCI Formulators’ Roundtable. The discussions will bring together the technical experts in formulated household products along with learnings from other sectors that can be applied, new ways of thinking, and students who can develop future solutions. The format will be interactive including invited talks as well as brainstorming and problem-solving sessions with the goal of developing a plan (and publication) to better incorporate sustainable chemistry in the supply chain. The workshop will explore: (1) How to drive change, with lessons from past successes; (2) Goals, barriers to achieving those goals, and consensus on what success looks like; (3) Developing a plan forward, including recommendations. The workshop is being organized in partnership with the ACS Committee on Environmental Improvement (CEI).

Towards Safer Design Strategies: Using Toxicology Tools and Concepts within Chemistry Courses and Programs

Session Organizers: Amy Cannon, Ph.D., Beyond Benign; Dalila Kovacs, Ph.D., Grand Valley State University; Pamela Spencer, Ph.D., Angus Chemical; Saskia van Bergen, Washington State Department of Ecology

Toxicology tools and concepts are essential in chemistry courses and programs to develop an understanding of toxicological principles and chemical safety that are traditionally absent from the chemistry curriculum. These concepts are also important in the design of chemical products and processes that have reduced health and environmental hazards. Toxicology can enable scientists to better predict hazards at the molecular level, therefore avoiding the use and generation of hazardous chemicals. Today, there is a movement towards teaching toxicology concepts to chemistry students and professionals in order to better prepare scientists with the skills to design products and processes with reduced hazards.

This symposium will feature: 1) professional toxicologists and chemists who actively use toxicology tools in their practical design of safer chemical products and processes, and 2) faculty members who have adopted toxicology concepts and practices within their chemistry courses and programs. Symposium speakers will provide short lectures on their area of expertise and demonstrate with tools they use in their daily practice, and share curriculum models.

Chemistry in Water – Following Nature’s Lead (Invited Presenters Only)

Session Organizer: Wilfried Braje, Principal Scientist, AbbVie

This symposium features the development of new synthetic chemistry from both academic and industrial labs that document not only that waste creation can be minimized, but that by going green, “faster, better, cheaper” processes oftentimes can be anticipated.

Notwithstanding the extraordinary advances being made in synthetic organic chemistry and organometallic catalysis, in particular, the manner in which this discipline has been, and continues to be practiced is simply not sustainable. The enormous amounts of organic waste being generated, the investment of energy in the form of heating and cooling of reactions, and the consumption of endangered metal-catalysts at an ever-increasing rate have all become important considerations for a sustainable future. Fortunately, new technologies are starting to accrue suggesting that synthetic chemistry need no longer be done at the expense of the environment; that the same, useful processes can, in fact, be developed hand-in-hand with the principles of green chemistry.

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