Greener Practices in Peptide and Oligonucleotide Synthesis

Organizer: Michael E. Kopach, Senior Research Advisor, Eli Lilly and Company, Indianapolis, IN, USA

Peptide and Oligonucleotide products are an area of significant growth within the biopharma industry. However, the current state of the art in peptide and oligonucleotide syntheses utilize primarily legacy technologies, with little focus on green chemistry and engineering. Waste generated from current peptide and oligonucleotide processes ranges  from 3,000-15,000 kg/kg API (10-50-mer products) with multiple usages of highly hazardous reagents and solvents. Contributing to the poor environmental profile is the pervasive and extensive use of chromatography to produce peptide and oligonucleotide products with required quality attributes. This session will explore how improved synthetic methodologies, safer coupling reagents, solvent selection, and minimization of chromatography play a vital role in improving the green chemistry profile for peptide and oligonucleotide processes.

Making Organic Chemistry More Sustainable

Organizer: David Leahy, Associate Director, Takeda Pharmaceuticals

The development of new synthetic methodologies and strategies has been the cornerstone upon which sustainable industrial processes are built. The pure research advances arising from academia fuel the world’s industrial innovation, while also training the scientific leaders of tomorrow. This special session highlights the research of graduate students and post-doctoral fellows across the broader organic chemistry community, which has the potential to impact sustainable industrial chemistry.

Presenters in the session received travel funding from the ACS GCI Pharmaceutical Roundtable.