Data-Rich Experimentation in Flow Chemistry

Organizers: Michael Di Maso & Jonathan McMullen, Merck

Cosponsor: ACS Green Chemistry Institute Pharmaceutical Roundtable

Advancements in continuous processing technologies in parallel with the expansion of complex organic reactions enabled by flow chemistry lead to widespread application of flow reactions in academic and industrial settings. The small internal volume, the ability to tune reaction conditions precisely, and the geometry of flow reactors renders them ideal tools for scaling reactions that are challenging or prohibitive in batch, such as highly exothermic, electrochemical, and photochemical reactions. While this technology enables seamless scale up of these reactions, development and optimization of flow reactions in the lab can be slow and resource intensive. This session will highlight the use of automation and new tools and methodologies to minimize the resources and time required to optimize reactions either in flow or in other systems with results that are easily transferrable to a flow reactor.