Green Toxicology: Making Hazard and Exposure Part of the Green Chemistry System
Symposium Organizers: Alexandra Maertens, Research Associate, Center for Alternatives to Animal Testing, Johns Hopkins University; Thomas Hartung, Doerenkamp-Zbinden Chair for Evidence-Based Toxicology and Director of the Center for Alternatives to Animal Testing, Johns Hopkins University, and; Emily Golden, Doctoral Student, Johns Hopkins University
Green Chemistry Principle #4, which states that “Chemical products should be designed to preserve efficacy of function while reducing toxicity”, has been described as the least developed principle of green chemistry. While other aspects of green chemistry—such as atom economy—have simple and well-developed metrics, hazard and exposure are more difficult to measure in ways that allow chemists to incorporate them into their design.
Green Toxicology is an emerging discipline that seeks to provide a framework for integrating the principles of toxicology into the design of safer chemicals using 21st century toxicology tools (e.g., including high-dimensional data, computational approaches, and systems level thinking) to look not just at chemicals in isolation but their exposure scenarios, as well as transformation and degradation products.