Greener Peptide and Oligonucleotide Syntheses
Session Organizer: Michael E. Kopach, Research Advisor, Eli Lilly and Company
Peptide and Oligonucleotide products are an area of significant growth within the biopharma industry. However, the current state of the art in peptide and oligonucleotide syntheses utilize primarily legacy technologies, with little focus on green chemistry and engineering. Waste generated from current peptide and oligonucleotide processes ranges from 3,000-15,000 kg/kg API (10-50 mer products) with multiple usages of highly hazardous reagents and solvents. Contributing to the poor environmental profile is the pervasive and extensive use of chromatography to produce peptide and oligonucleotide products with required quality attributes. This session will explore how improved synthetic methodologies, safer coupling reagents, solvent selection, and minimization of chromatography play a vital role in improving the green chemistry profile for peptide and oligonucleotide processes.