26th Annual Green Chemistry & Engineering Conference

Greener peptide and oligonucleotide synthesis

Organizer: Mike Kopach   

Peptide and Oligonucleotide products are an area of  significant growth within the biopharma industry. However, the  current state of the art in peptide and oligonucleotide syntheses utilize primarily legacy technologies, with little focus on green chemistry and engineering. Waste generated  from current peptide and oligonucleotide processes can range  from 3,000-15,000 kg/kg API  with multiple usages of highly hazardous reagents and solvents. Contributing to the poor environmental profile is the pervasive and extensive use of chromatography to produce peptide and oligonucleotide products with required quality attributes. This session will explore how improved synthetic methodologies, safer coupling reagents, solvent selection, and minimization of  chromatography play a vital role in improving the environmental footprint for peptide and oligonucleotide processes.

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