26th Annual Green Chemistry & Engineering Conference

Tag: toxicology

Information Driving Greener Design: Uncertainty in estimating systems accuracy and its impact on decision-making

Organizers: Hans Plugge, Senior Toxicologist, Manager Safer Chemical Analytics, Verisk 3E; Jakub Kostal, George Washington University; Emma Lavoie, EPA

This session focuses on the often controversial and challenging topic of uncertainty in toxicological data and regulatory decision-making. Practitioners must often reconcile data from multiple sources and types of data (e.g. in silico, in vitro, in vivo), which may rely on widely different protocols and approximations. The sheer magnitude of available in silico and in vitro data is both crucial to advancing the assessment of industrial chemicals and their inherent risks, as well as problematic, as it limits human review and expert judgment of data quality. It is important to stress that the magnitude and diversity of datasets available for regulatory assessments will increase in future years as a result of the push for integrated testing strategies. The session format aims for roundtable-style discussions, engaging stakeholders from academia, industry and government. Discussion will follow the ‘storyline’ of problems encountered and available solutions, progressing from i) uncertainty in raw experimental and computational model data, ii) uncertainty in combining multiple data sources and types, iii) approaches to incorporating uncertainty in toxicology, environmental health and chemical databases, iv) strategies for handling uncertainty in regulatory decision-making, and v) communicating uncertainty in public dissemination of toxicological data and assessments.

Information Driving Greener Design: Design & Use of Safer Chemicals to Meet Market Demand

Organizers: Bridget Williams, US EPA Safer Choice Program; Kathleen Compton, Pollution Prevention Coordinator, US EPA Region 10; Kendra Tyler, Safer Choice Lead, US EPA Region 10

Chemical design to meet marketing needs can sometimes overlook chemical safety considerations, or focus on eliminating a single concern, such as carcinogenicity. Chemical design to avoid a certain hazard endpoint is an approach that, if not pursued in the context of a broader goal, could lead to the design or use of a chemical with another problematic endpoint such as persistence, reproductive toxicity, or chronic toxicity. Methodologies for identifying safer chemicals include assessment by functional class and comparing the most relevant endpoints for that class. Understanding a chemical’s structure and function is key to determining which hazard endpoints might be distinguishing and potentially problematic. Using this approach furthers the advancement of green chemistry through the design of less hazardous chemicals. The symposium will discuss safer chemical design, include industry examples, share green chemistry challenges in the marketplace, and offer examples of how organizations are supporting the development of safer alternatives.

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